PARP Inhibition in Cancer: An Update on Clinical Development
Abstract
PARP (poly(ADP-ribose) polymerase) inhibitors represent a novel class of anti-cancer therapy; they take advantage of synthetic lethality and induce cell death by exploiting a defect in DNA repair. This class of medication was initially evaluated in patients with BRCA-associated tumors, but efficacy was also demonstrated in other populations. Since 2014, four PARP inhibitors have been approved in various indications: olaparib, niraparib, and...
Paper Details
Title
PARP Inhibition in Cancer: An Update on Clinical Development
Published Date
Oct 17, 2019
Journal
Volume
14
Issue
6
Pages
657 - 679
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Notes
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