Identification and characterization of Cardiac Glycosides as senolytic compounds
Abstract
Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence in aging and offer therapeutic interventions. Here we report the identification of Cardiac Glycosides (CGs) as a family of compounds with senolytic activity. CGs, by targeting the Na+/K+ATPase pump, cause a disbalanced electrochemical gradient within the cell causing depolarization and acidification. Senescent cells present...
Paper Details
Title
Identification and characterization of Cardiac Glycosides as senolytic compounds
Published Date
Oct 21, 2019
Journal
Volume
10
Issue
1
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