D₂ autoreceptor switches CB₂ receptor effects on [³H]‐dopamine release in the striatum

CB 2 receptors (CB 2 R) are expressed in midbrain neurons. To evidence the control of dopamine release in dorsal striatum by CB 2 R, we performed experiments of [ 3 H]‐dopamine release in dorsal striatal slices. We found a paradoxical increase in K + ‐induced [ 3 H]‐dopamine release by CB 2 R activation with GW 833972A and JWH 133 two selective agonist. To understand the mechanism involved, we tested for a role of the D 2 autoreceptor in this...