Deficiency of NONO is associated with impaired cardiac function and fibrosis in mice
Abstract
Non-POU-domain-containing octamer-binding protein (NONO), a component of multifunctional Drosophila behavior/human splicing (DBHS) family, plays an important role in regulating glucose and fat metabolism, circadian cycles, cell division, collagen formation and fibrosis. Dysfunctional variants of NONO have been described as the cause of congenital heart defects in males. However, the effects of NONO deficiency on the ventricular function and...
Paper Details
Title
Deficiency of NONO is associated with impaired cardiac function and fibrosis in mice
Published Date
Dec 1, 2019
Volume
137
Pages
46 - 58
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