A microtranslatome coordinately regulates sodium and potassium currents in the human heart
Abstract
Catastrophic arrhythmias and sudden cardiac death can occur with even a small imbalance between inward sodium currents and outward potassium currents, but mechanisms establishing this critical balance are not understood. Here, we show that mRNA transcripts encoding INa and IKr channels (SCN5A and hERG, respectively) are associated in defined complexes during protein translation. Using biochemical, electrophysiological and single-molecule...
Paper Details
Title
A microtranslatome coordinately regulates sodium and potassium currents in the human heart
Published Date
Oct 31, 2019
Journal
Volume
8
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