FAAH inhibition as a preventive treatment for migraine: A pre-clinical study
Abstract
Fatty-acid amide hydrolase (FAAH) is an intracellular serine hydrolase that catalyzes the cleavage of endogenous fatty-acid amides, including the endocannabinoid anandamide (AEA). We previously reported that the peripherally restricted FAAH inhibitor URB937, which selectively increases AEA levels outside the central nervous system, reduces hyperalgesia and c-Fos expression in the trigeminal nucleus caudalis (TNC) and the locus coeruleus in an...
Paper Details
Title
FAAH inhibition as a preventive treatment for migraine: A pre-clinical study
Published Date
Feb 1, 2020
Journal
Volume
134
Pages
104624 - 104624
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Notes
History