DPI Selectively Inhibits Intracellular NADPH Oxidase Activity in Human Neutrophils
Abstract
Neutrophils are capable of producing significant amounts of reactive oxygen species (ROS) by the phagocyte NADPH oxidase, which consists of membrane-bound and cytoplasmic subunits that assemble during activation. Neutrophils harbor two distinct pools of the membrane-localized oxidase components, one expressed in the plasma membrane and one in the membranes of intracellular granules. Assembly of active oxidase at either type of membrane leads to...
Paper Details
Title
DPI Selectively Inhibits Intracellular NADPH Oxidase Activity in Human Neutrophils
Published Date
Oct 1, 2019
Journal
Volume
3
Issue
10
Pages
488 - 497
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