P2-137: AN E-QTL META-ANALYSIS OF BRAIN CORTICAL TISSUE ACROSS FIVE CONSORTIUM-BASED STUDIES

Neuropsychiatric disorders such as Alzheimer's disease (AD) are known to carry polygenic risk architectures. At present, most risk loci for AD fall in non-coding regions of the genome and provide no actionable insight for therapeutic targets. Hence, understanding the effect of these risk loci on epigenetic, molecular and cellular phenotypes are necessary in elucidating primary symptomatic features of AD like neuronal degeneration. To this end,...