Accurate chromosome-scale haplotype-resolved assembly of human genomes

Pages: 810341
Published: Jul 1, 2020
Abstract
Haplotype-resolved or phased sequence assembly provides a complete picture of genomes and complex genetic variations. However, current phased assembly algorithms either fail to generate chromosome-scale phasing or require pedigree information, which limits their application. We present a method that leverages long accurate reads and long-range conformation data for single individuals to generate chromosome-scale phased assembly within a day....
Paper Details
Title
Accurate chromosome-scale haplotype-resolved assembly of human genomes
Published Date
Jul 1, 2020
Journal
Pages
810341
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