Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds
Abstract
Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) represent the best cell source for cardiac regenerative purposes but retain an immature phenotype after differentiation with significant limitations compared to adult cardiomyocytes. Apart from an incomplete cardiomyocyte-specific structure and microarchitecture, cells show at the level of Ca2+ signaling only slow Ca2+ release and reuptake properties. Here, we investigated the...
Paper Details
Title
Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds
Published Date
Jan 1, 2020
Journal
Volume
227
Pages
119551 - 119551
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