Shp2 in myocytes is essential for cardiovascular and neointima development

Volume: 137, Pages: 71 - 81
Published: Dec 1, 2019
Abstract
Mutations in the PTPN11 gene, which encodes the protein tyrosine phosphatase Shp2, cause Noonan syndrome and LEOPARD syndrome, inherited multifaceted diseases including cardiac and vascular defects. However, the function of Shp2 in blood vessels, especially in vascular smooth muscle cells (VSMCs), remains largely unknown. We generated mice in which Shp2 was specifically deleted in VSMCs and embryonic cardiomyocytes using the SM22α-Cre transgenic...
Paper Details
Title
Shp2 in myocytes is essential for cardiovascular and neointima development
Published Date
Dec 1, 2019
Volume
137
Pages
71 - 81
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