P3-199: PTPN11 IS INVOLVED IN REGULATING TAU PROTEIN PHOSPHORYLATION IN THE RETINA

Tau is an axonally expressed microtubule-associated protein that plays a critical role in maintenance of neuronal structure and function. Tau phosphorylation is associated with neurofibrillary tangle formation in the brain in Alzheimer's disease (AD). Substantial research has shown that retinal ganglion cell (RGC) function is also negatively affected in AD. AD pathology in the retina demonstrates molecular overlap with pathological features...