Multiday maintenance of extracorporeal lungs using cross-circulation with conscious swine

Lung remains the least-utilized solid organ for transplantation. Efforts to recover donor lungs with reversible injuries using ex vivo perfusion systems are limited to <24 hours of support. Here, we demonstrate the feasibility of extending normothermic extracorporeal lung support to 4 days using cross-circulation with conscious swine.A swine behavioral training program and custom enclosure were developed to enable multiday cross-circulation...