A spatial similarity of stereochemical environments formed by amino acid residues defines a common epitope of two non-homologous proteins
Abstract
It is critical for development of high-quality antibodies in research and diagnostics to predict accurately their cross-reactivities with “off-target” molecules, which potentially induce false results. Herein, we report a good example of such a cross-reactivity for an off-target due to a stereochemical environment of epitopes, which does not simply depend on amino acid sequences. We found that significant subpopulation of a polyclonal peptide...
Paper Details
Title
A spatial similarity of stereochemical environments formed by amino acid residues defines a common epitope of two non-homologous proteins
Published Date
Oct 15, 2019
Journal
Volume
9
Issue
1
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