Signal transduction pathways regulating Drosophila ovarian germline stem cells

Drosophila female germline stem cells (GSCs) serve as one of the best understood stem cell types. GSCs reside in a special microenvironment, the stem cell niche, and their activity is tightly regulated by niche-derived signals. In addition to the stemness-promoting signaling molecules, the niche also generates other signaling molecules that regulate GSC differentiation. Recent studies are beginning to appreciate the intricate interactions among...