Match!

The association of plasma fatty acids with hand and knee osteoarthritis: the NEO study

Published on Feb 1, 2020in Osteoarthritis and Cartilage4.879
· DOI :10.1016/j.joca.2019.10.002
Marieke Loef3
Estimated H-index: 3
(LUMC: Leiden University Medical Center),
Andreea Ioan-Facsinay31
Estimated H-index: 31
(LUMC: Leiden University Medical Center)
+ 4 AuthorsFrits R. Rosendaal118
Estimated H-index: 118
(LUMC: Leiden University Medical Center)
Sources
Abstract
Abstract Objective To investigate the association of postprandial and fasting plasma saturated fatty acid (SFAs), monounsaturated fatty acid (MUFAs) and polyunsaturated fatty acid (PUFAs) concentrations with hand and knee osteoarthritis (OA). Design In the population-based NEO study clinical hand and knee OA were defined by the ACR classification criteria. Structural knee OA was defined on MRI. Hand and knee pain was determined by AUSCAN and KOOS, respectively. Plasma was sampled fasted and 150 minutes after a standardized meal, and subsequently analysed using a nuclear magnetic resonance platform. Logistic regression analyses were used to investigate the association of total fatty acid, SFA, MUFA, total PUFA, omega-3 PUFA and omega-6 PUFA concentrations with clinical hand and knee OA, structural knee OA and hand and knee pain. Fatty acid concentrations were standardized (mean 0, SD 1). Analyses were stratified by sex and corrected for age, education, ethnicity and total body fat percentage. Results Of the 5,328 participants (mean age 56 years, 58% women) 7% was classified with hand OA, 10% with knee OA and 4% with concurrent hand and knee OA. In men, postprandial SFAs (OR (95% CI)) 1.23 (1.00; 1.50), total PUFAs 1.26 (1.00; 1.58) and omega-3 PUFAs 1.24 (1.01; 1.52) were associated with hand OA. SFAs and PUFAs were associated with structural, but not clinical knee OA. Association of fasting fatty acid concentrations were weaker than postprandial concentrations. Conclusion Plasma postprandial SFA and PUFA levels were positively associated with clinical hand and structural knee OA in men, but not in women.
  • References (38)
  • Citations (0)
📖 Papers frequently viewed together
7 Authors (Hui Li, ..., Guang-hua Lei)
8 Citations
2019
5 Authors (S R Angelia, ..., N Mudjihartini)
78% of Scinapse members use related papers. After signing in, all features are FREE.
References38
Newest
#1Sunderajhan SekarH-Index: 4
Last. Yin XiaoH-Index: 49
view all 7 authors...
Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats
16 CitationsSource
#1Bing Lu (Brigham and Women's Hospital)H-Index: 31
#2Jeffrey B. Driban (Tufts Medical Center)H-Index: 24
Last. Charles B. Eaton (Brown University)H-Index: 54
view all 6 authors...
Objective Few studies have investigated the role of dietary factors on knee osteoarthritis (OA) progression. We examined the prospective association of dietary fat intake with radiographic progression of knee OA. Methods In the Osteoarthritis Initiative, 2,092 participants with radiographic knee OA and having baseline dietary data were followed at yearly intervals up to 48 months. Dietary intakes of fatty acids were assessed with the Block Brief Food Frequency Questionnaire. To evaluate radiogra...
21 CitationsSource
#1Féline P.B. Kroon (LUMC: Leiden University Medical Center)H-Index: 11
#2Sofia Ramiro (LUMC: Leiden University Medical Center)H-Index: 27
Last. Margreet Kloppenburg (LUMC: Leiden University Medical Center)H-Index: 53
view all 6 authors...
6 CitationsSource
#1Meric Erikci Ertunc (Harvard University)H-Index: 3
#2Gökhan S. Hotamisligil (Harvard University)H-Index: 100
96 CitationsSource
#1Stephen J. MehlerH-Index: 1
#2Lauren R. MayH-Index: 2
Last. Zubin Shah (New York Institute of Technology College of Osteopathic Medicine)H-Index: 1
view all 5 authors...
Abstract Background Osteoarthritis (OA) in dogs is a prevalent and serious condition. The most common treatment for the clinical signs of OA in dogs is the administration of nonsteroidal antiiflammatory pharmaceuticals. Omega-3 ( n− 3) fatty acids have been shown to reduce the clinical signs of osteoarthritis in dogs. Objective The primary goals of this study were 1) to determine the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the clinical signs of OA in dogs, 2) to ...
12 CitationsSource
#1Johannes KettunenH-Index: 45
#2Ayşe Demirkan (EUR: Erasmus University Rotterdam)H-Index: 3
Last. Mika Ala-KorpelaH-Index: 47
view all 50 authors...
Genome-wide association studies have identified numerous loci linked with complex diseases, for which the molecular mechanisms remain largely unclear. Comprehensive molecular profiling of circulating metabolites captures highly heritable traits, which can help to uncover metabolic pathophysiology underlying established disease variants. We conduct an extended genome-wide association study of genetic influences on 123 circulating metabolic traits quantified by nuclear magnetic resonance metabolom...
174 CitationsSource
#1Catherine J. Hill (University of Adelaide)H-Index: 48
#2Lyn March (RNSH: Royal North Shore Hospital)H-Index: 68
Last. Graeme Jones (Menzies Research Institute)H-Index: 73
view all 11 authors...
Objectives To determine whether high-dose fish oil is superior to low-dose supplementation for symptomatic and structural outcomes in knee osteoarthritis (OA). Methods A randomised, double-blind, multicentre trial enrolled 202 patients with knee OA and regular knee pain. They were randomised 1:1 to high-dose fish oil (4.5 g omega-3 fatty acids) 15 mL/day or (2) low-dose fish oil (blend of fish oil and sunola oil; ratio of 1:9, 0.45 g omega-3 fatty acids) 15 mL/day. The primary endpoints were Wes...
40 CitationsSource
#1Chia-Lung Wu (Duke University)H-Index: 11
#2Deeptee Jain (Duke University)H-Index: 8
Last. Farshid Guilak (Duke University)H-Index: 92
view all 10 authors...
Objective The mechanisms linking obesity and osteoarthritis (OA) are not fully understood and have been generally attributed to increased weight, rather than metabolic or inflammatory factors. Here, we examined the influence of fatty acids, adipokines, and body weight on OA following joint injury in an obese mouse model. Methods Mice were fed high-fat diets rich in various fatty acids (FA) including saturated FAs (SFAs), ω-6 polyunsaturated FAs (PUFAs), and ω-3 PUFAs. OA was induced by destabili...
58 CitationsSource
#1Jingyu Cai (Anhui Medical University)H-Index: 4
#2Jianhua Xu (UTAS: University of Tasmania)H-Index: 2
Last. Changhai DingH-Index: 45
view all 10 authors...
Objective. The function of the infrapatellar fat pad (IPFP) in knee osteoarthritis (OA) remains uncertain. This study aimed to examine cross-sectional associations between IPFP volume and knee structures in patients with knee OA. Methods. The study included 174 patients with clinical knee OA (mean age, 55.5 yrs). Fat-suppressed 3-D T1-weighted spoiled gradient recall magnetic resonance imaging (MRI) was used to measure the IPFP and cartilage volume. T2-weighted fast spin echo MRI was used to ass...
37 CitationsSource
#1Hongming MiaoH-Index: 10
#2Liang ChenH-Index: 1
Last. Houjie LiangH-Index: 22
view all 7 authors...
The biomechanics stress and chronic inflammation in obesity are causally linked to osteoarthritis. However, the metabolic factors mediating obesity-related osteoarthritis are still obscure. Here we scanned and identified at least two elevated metabolites (stearic acid and lactate) from the plasma of diet-induced obese mice. We found that stearic acid potentiated LDH-a-dependent production of lactate, which further stabilized HIF1α protein and increased VEGF and proinflammatory cytokine expressio...
24 CitationsSource
Cited By0
Newest