A novel toolkit for the efficient delivery of Cas9/sgRNA complexes to chromosomes in cells
Abstract
Introductory paragraph null The application of gene editing technology is currently limited by the lack of safe and efficient methods to deliver RNA-guided endonucleases to target cells. We engineered lentivirus-based nanoparticles to copackage the U6-sgRNA template and the CRISPR-associated protein 9 (Cas9) fused with a virion-targeted protein Vpr (Vpr.Prot.Cas9), for simultaneous delivery to cells. In addition to Vpr, equal spatiotemporal...
Paper Details
Title
A novel toolkit for the efficient delivery of Cas9/sgRNA complexes to chromosomes in cells
Published Date
Oct 21, 2019
Journal
Pages
812925
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