DNA methylation modules associate with incident cardiovascular disease and cumulative risk factor exposure

Epigenome-wide association studies using DNA methylation have the potential to uncover novel biomarkers and mechanisms of cardiovascular disease (CVD) risk. However, the direction of causation for these associations is not always clear, and investigations to-date have often failed to replicate at the level of individual loci.Here, we undertook module- and region-based DNA methylation analyses of incident CVD in the Women's Health Initiative...