What Is GLP-1 Really Doing in Obesity?

GLP-1 is an antidiabetic hormone released from the gut in response to nutrient ingestion. Many studies have evaluated whether GLP-1 secretion is reduced, increased, or neither in the obese, glucose-intolerant (impaired glucose tolerance), or diabetic status. In human and animal studies, reduced GLP-1 secretion in response to nutritional stimulation was reported, while unchanged or increased GLP-1 responses were also demonstrated. By monitoring...