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Circulating Very-Long-Chain SFA Concentrations Are Inversely Associated with Incident Type 2 Diabetes in US Men and Women

Published on Oct 16, 2019in Journal of Nutrition4.416
路 DOI :10.1093/jn/nxz240
Andres V. Ardisson Korat5
Estimated H-index: 5
(Harvard University),
Vasanti S. Malik36
Estimated H-index: 36
(Harvard University)
+ 7 AuthorsQi Sun62
Estimated H-index: 62
(Harvard University)
Abstract
  • References (53)
  • Citations (1)
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References53
Newest
#1Amanda M. FrettsH-Index: 18
#2Fumiaki Imamura (University of Cambridge)H-Index: 27
Last. Rozenn N. Lemaitre (UW: University of Washington)H-Index: 61
view all 40 authors...
BACKGROUND: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. OBJECTIVE: We investigated the associations of circulating VLSFAs 20:0, ...
4 CitationsSource
#1Carlos Guill茅n (Complutense University of Madrid)H-Index: 14
#2Manuel Benito (Complutense University of Madrid)H-Index: 47
Type 2 Diabetes Mellitus (T2DM), a worldwide epidemics, is a progressive disease initially developing an insulin resistant, with a manifest pancreatic beta islets hyperplasia/hypertrophy and hyperinsulinemia. As the disease progresses, pancreatic 尾 cells are overwhelmed and fails in their capacity to compensate insulin resistance. In addition, it is usually associated with other metabolic diseases such as hyperlipidemia, obesity and the metabolic syndrome. During the progression to T2DM there is...
3 CitationsSource
#1Mika HilvoH-Index: 25
#2Tuire Salonurmi (OUH: Oulu University Hospital)H-Index: 9
Last. Pekka Jousilahti (National Institute for Health and Welfare)H-Index: 77
view all 14 authors...
Ceramide lipids have a role in the development of insulin resistance, diabetes and risk of cardiovascular disease. Here we investigated four ceramides and their ratios to find the best predictors of incident diabetes. A validated mass-spectrometric method was applied to measure Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0) and Cer(d18:1/24:1) from serum or plasma samples. These ceramides were analysed in a population-based risk factor study (FINRISK 2002, n鈥=鈥8045), in a cohort of participan...
15 CitationsSource
#1Jason H.Y. Wu (The George Institute for Global Health)H-Index: 35
#2Matti Marklund (Uppsala University)H-Index: 12
Last. Dariush Mozaffarian (Tufts University)H-Index: 120
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Summary Background The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabetes. Methods We did a pooled analysis of new, harmonised, individual-level analyses for the biomarkers linoleic acid and its metabolite arachidonic acid and incident type 2 di...
57 CitationsSource
#1A. Eltweri (University Hospitals of Leicester NHS Trust)H-Index: 2
#2Anne L. Thomas (University of Leicester)H-Index: 18
Last. David J. Bowrey (University Hospitals of Leicester NHS Trust)H-Index: 8
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Summary Background It has been demonstrated that short term intravenous (IV) administration of omega-3 polyunsaturated fatty acids (PUFAs) is more effective than oral supplementation at promoting incorporation of the bioactive omega-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into plasma, blood cells and tissues. The effect of repeated short term IV infusion of omega-3 PUFAs was investigated in patients with advanced oesophagogastric cancer during palliative chemotherapy. ...
4 CitationsSource
#1Magdalene K. Montgomery (UNSW: University of New South Wales)H-Index: 13
#2Simon H. J. Brown (Illawarra Health & Medical Research Institute)H-Index: 21
Last. Nigel Turner (UNSW: University of New South Wales)H-Index: 46
view all 13 authors...
Abstract In a recent study, we showed that in response to high fat feeding C57BL/6, 129X1, DBA/2 and FVB/N mice all developed glucose intolerance, while BALB/c mice displayed minimal deterioration in glucose tolerance and insulin action. Lipidomic analysis of livers across these five strains has revealed marked strain-specific differences in ceramide (Cer) and sphingomyelin (SM) species with high-fat feeding; with increases in C16-C22 (long-chain) and reductions in C聽>聽22 (very long-chain) Cer a...
25 CitationsSource
#1Pei Shi Ong (NUS: National University of Singapore)H-Index: 9
#2Louis Zizhao Wang (NUS: National University of Singapore)H-Index: 3
Last. Gautam Sethi (NUS: National University of Singapore)H-Index: 73
view all 6 authors...
The mechanistic target of rapamycin (mTOR), via its two distinct multiprotein complexes, mTORC1 and mTORC2, plays a central role in the regulation of cellular growth, metabolism and migration. A dysregulation of the mTOR pathway has in turn been implicated in several pathological conditions including insulin resistance and cancer. Overactivation of mTORC1 and disruption of mTORC2 function have been reported to induce insulin resistance. On the other hand, aberrant mTORC1 and mTORC2 signaling via...
18 CitationsSource
#1Ju Yong Bae (Dong-a University)H-Index: 5
#2Ki Ok Shin (Dong-a University)H-Index: 7
Last. Sunghwun Kang (Kangwon National University)H-Index: 3
view all 7 authors...
[Purpose] The purpose of this study was to investigate the effect of exercise and dietary change on obesity and insulin resistance and mTOR signaling protein levels in skeletal muscles of obese rats.
6 CitationsSource
#1Zhixin Guo (Inner Mongolia University)H-Index: 2
#2Yanfeng Wang (Inner Mongolia University)H-Index: 4
Last. Zhigang Wang (Inner Mongolia University)H-Index: 4
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Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth and metabolism and is sufficient to induce specific metabolic processes, including de novo lipid biosynthesis. Elongation of very-long-chain fatty acids 1 (ELOVL1) is a ubiquitously expressed gene and the product of which was thought to be associated with elongation of carbon (C) chain in fatty acids. In the present study, we examined the effects of rapamycin, a specific inhibitor of mTORC1, on ELOVL1 expressi...
2 CitationsSource
#1Vasanti S. Malik (Harvard University)H-Index: 36
#2Stephanie E. Chiuve (Harvard University)H-Index: 45
Last. Qi Sun (Harvard University)H-Index: 62
view all 7 authors...
Background鈥擟irculating very-long-chain saturated fatty acids (VLCSFAs) may play an active role in the origin of cardiometabolic diseases. Methods and Results鈥擶e measured 3 VLCSFAs (C20:0, C22:0, and C24:0) in plasma and erythrocytes using gas-liquid chromatography among 794 incident coronary heart disease (CHD) cases who were prospectively identified and confirmed among women in the Nurses鈥 Health Study (NHS; 1990鈥2006) and among men in the Health Professionals Follow-Up Study (HPFS; 1994鈥2008)....
23 CitationsSource
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The metabolic syndrome is a multifactorial disease developed due to accumulation and chronification of several risk factors associated with disrupted metabolism. The early detection of the biomarkers by NMR spectroscopy could be helpful to prevent multifactorial diseases. The exposure of each risk factor can be detected by traditional molecular markers but the current biomarkers have not been enough precise to detect the primary stages of disease. Thus, there is a need to obtain novel molecular ...
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