The genetic underpinnings of obesity

Obesity has now reached pandemic levels, with a quarter of the world’s population being overweight or obese and thus at a greater risk of developing type 2 diabetes (T2D) and cardiovascular disease (CVD) [1•]. Largescale biobanks, combined with genome-wide discovery efforts, have identified thousands of loci associated with obesity traits including body composition, fat distribution and their causal relationships with disease risk. These...