NS8593 inhibits Ca2+ permeant channels reversing mouse airway smooth muscle contraction

This study focused on investigating whether NS8593 reverses airway smooth muscle (ASM) contraction and the underlying mechanism. ASM contraction in mouse tracheal rings and lung slices was measured. Currents mediated by voltage dependent Ca2+ channels (VDCCs) and ACH-activated channels were measured using the whole-cell patch-clamp technique in single tracheal smooth muscle cells (TSMCs). Intracellular Ca2+ level and cell length were measured...