Simulation of Chemotherapy Effects in Older Breast Cancer Patients With High Recurrence Scores

Background Tumor genomic expression profile data are used to guide chemotherapy choice, but there are gaps in evidence for women aged 65 years and older. We estimate chemotherapy effects by age and comorbidity level among women with early-stage, hormone receptor–positive, human epidermal growth factor receptor 2 (HER2)–negative breast cancers and Oncotype DX scores of 26 or higher. Methods A discrete-time stochastic state transition simulation...