Structural basis of temperature sensation by the TRP channel TRPV3
Volume: 26, Issue: 11, Pages: 994 - 998
Published: Oct 21, 2019
Abstract
We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel pore remains closed while S6 helices undergo α-to-π transitions. During the weakly temperature-dependent second step, channel opening, tight association of the S1-S4 and pore domains is stabilized by changes in the...
Paper Details
Title
Structural basis of temperature sensation by the TRP channel TRPV3
Published Date
Oct 21, 2019
Volume
26
Issue
11
Pages
994 - 998
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History