P4-210: DISENTANGLING THE RELATIONSHIP BETWEEN SYNAPTIC AND NEURODEGENERATION CEREBROSPINAL FLUID BIOMARKERS IN ALZHEIMER'S DISEASE

A biomarker of synapse loss, an early event in Alzheimer's disease (AD) pathophysiology, could be a much-needed prognostic biomarker. A potential candidate is sAPPβ, which has recently been identified as a GABABR1A ligand. In addition, we previously identified 5 synaptic proteins (Calsyntenin-1, GluR4, Neurexin-2A, Neurexin-3A, Thy-1) that showed changes in cerebrospinal fluid (CSF) that precede markers of neurodegeneration but may partially...