The C. elegans cysteine-string protein homologue, DNJ-14, is dispensable for neuromuscular junction maintenance across ageing

Maintenance of synaptic function across ageing is vital in sustaining cognitive function. Synaptic dysfunction is a key part of the pathophysiology of a number of neurodegenerative diseases. The synaptic co-chaperone, cysteine-string protein (CSP), is important for synaptic maintenance and function in Drosophila, mice, and humans, and disruption of CSP results in synaptic degeneration. We sought to characterize synaptic ageing in C. elegans upon...