Functionally-informed fine-mapping and polygenic localization of complex trait heritability

Published: Oct 17, 2019
Abstract
Fine-mapping aims to identify causal variants impacting complex traits. Several recent methods improve fine-mapping accuracy by prioritizing variants in enriched functional annotations. However, these methods can only use information at genome-wide significant loci (or a small number of functional annotations), severely limiting the benefit of functional data. We propose PolyFun, a computationally scalable framework to improve fine-mapping...
Paper Details
Title
Functionally-informed fine-mapping and polygenic localization of complex trait heritability
Published Date
Oct 17, 2019
Journal
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