Sam68 impedes the recovery of arterial injury by augmenting inflammatory response

Objective The role of Src-associated-in-mitosis-68-kDa (Sam68) in cardiovascular biology has not been studied. A recent report suggests that Sam68 promotes TNF-α–induced NF-κB activation in fibroblasts. Here we sought to dissect the molecular mechanism by which Sam68 regulates NF-κB signaling and its functional significance in vascular injury. Approach and results The endothelial denudation injury was induced in the carotid artery of Sam68-null...