Copy Number Variation of Multiple Genes in SAPHO Syndrome

Objective. SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome is a type of rare chronic aseptic inflammation of unknown etiology. To date, no research to our knowledge has reported copy number variation (CNV) of genes that could affect predisposition to SAPHO syndrome. We investigated the association between CNV profile and SAPHO syndrome. Methods. We used array comparative genomic hybridization (CGH) to screen for CNV in a...