Loneliness and depression dissociated on parietal-centered networks in cognitive and resting states

Background Perceived loneliness, an increasingly prevalent social issue, is closely associated with major depressive disorder (MDD). However, the neural mechanisms previously implicated in key cognitive and affective processes in loneliness and MDD still remain unclear. Such understanding is critical for delineating the psychobiological basis of the relationship between loneliness and MDD. Methods We isolated the unique and interactive cognitive...