Kinks in the chain: examining recombination‐activating gene scanning during V(D)J recombination

A diverse antigen receptor repertoire is key to adaptive immunity. This diversity relies on the recombination of three pools of gene segments within all antigen receptor loci.1-4 These pools are known as variable (V), diversity (D) and joining (J). Each antigen receptor loci contains a different number and arrangement of the gene segments. For example, the mouse immunoglobulin heavy chain (Igh) locus contains 113 VH segments, nine DH segments...