Mutations in the HRB linker of human parainfluenza virus type 3 fusion protein reveal its importance for fusion activity

Volume: 275, Pages: 197791 - 197791
Published: Jan 1, 2020
Abstract
Human parainfluenza virus type 3 (HPIV3) fuses the viral envelope with the host cell membrane through the concerted action of the fusion (F) protein and the hemagglutinin-neuraminidase (HN). Upon HN binding to sialic acid (SA), the F protein in a metastable prefusion form is activated to undergo a series of structural rearrangements into a stable postfusion form to actuate the fusion between membranes. Various domains of F protein of some other...
Paper Details
Title
Mutations in the HRB linker of human parainfluenza virus type 3 fusion protein reveal its importance for fusion activity
Published Date
Jan 1, 2020
Volume
275
Pages
197791 - 197791
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