P4-589: COMPARISON OF CEREBROSPINAL FLUID NEUROFILAMENT LIGHT CHAIN PROTEIN AND THREE MRI-BASED MORPHOMETRIC ESTIMATES FOR DEFINING NEURODEGENERATION (N) ACROSS THE ALZHEIMER'S DISEASE CONTINUUM

Hippocampal volume, global atrophy, and an “Alzheimer's disease (AD) signature” consisting of cortical thickness estimates from regions impacted early in AD are three of a number of MRI-based metrics available for defining neurodegeneration (N). Cerebrospinal fluid (CSF) levels of neurofilament light chain protein (NfL), a biomarker of axonal injury, has also been used to examine (N) in AD. This study compared three MRI-based measures and CSF...