Screening and production of an affibody inhibiting the interaction of the PD-1/PD-L1 immune checkpoint
Abstract
An affibody is a 58 amino acids peptide derived from the Z domain of staphylococcal protein A and generally applied in areas such as imaging diagnosis, clinical therapeutics and biotechnology research. To screen for an affibody targeting the immune checkpoint PD-L1, a combinatorial affibody library was generated in yeast using degenerate overlap PCR primers and In-fusion technology. Z-j1 and Z-j2 affibodies targeting the Ig-like V domain of...
Paper Details
Title
Screening and production of an affibody inhibiting the interaction of the PD-1/PD-L1 immune checkpoint
Published Date
Feb 1, 2020
Volume
166
Pages
105520 - 105520
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