41.2 NEURAL MARKERS AND CLINICAL RISK CALCULATION FOR PREDICTING BIPOLAR DISORDER

Family history is a potent risk factor for bipolar spectrum disorder (BPSD), although most offspring of parents with bipolar disorder will not develop BPSD. Neuroimaging studies assessing the differences between offspring of parents with bipolar disorder (OBP) and healthy control (HC) subjects have identified intrinsic functional connectivity (iFC) of the left inferior frontal gyrus (IFG) to be decreased in OBP. We recently developed a risk...