PHARMACOLOGICAL NOREPINEPHRINE TRANSPORTER INHIBITION FOR THE PREVENTION OF VASOVAGAL SYNCOPE: A SYSTEMATIC REVIEW AND META-ANALYSIS

Vasovagal syncope is a common clinical problem that significantly reduces quality of life yet lacks effective medical therapies. Pharmacological norepinephrine transporter (NET) inhibition increases sympathetic tone, leading to suggestions that it might be able to prevent hypotension and syncope. The objective of this systematic review and meta-analysis was to evaluate the ability of selective NET inhibitors – reboxetine, sibutramine, and...