Next generation sequencing targeted gene panel in Greek MODY patients increases diagnostic accuracy

Background Maturity Onset Diabetes of the Young (MODY) constitutes a genetically and clinically heterogeneous type of monogenic diabetes. It is characterized by early onset, autosomal dominant inheritance and a defect in pancreatic β-cell insulin secretion. To date, various MODY subtypes have been reported, each one of a distinct genetic etiology. Objective The aim of this study was to identify the molecular defects of 50 patients with MODY...