Prediction of Alzheimer's disease diagnosis within 14 years through Aβ misfolding in blood plasma compared to APOE4 status, and other risk factors

Introduction Alzheimer's disease (AD) has a long prodromal stage and identifying high‐risk individuals is critical. We aimed to investigate the ability of Aβ misfolding in blood plasma, APOE4 status, and dementia risk factors to predict diagnosis of AD. Methods Within a community‐based cohort, Aβ misfolding in plasma measured by immuno‐infrared sensor and APOE genotype were determined at baseline in 770 participants followed over 14 years....