Transforming growth factor beta 1 induces methylation changes in lung fibroblasts
Abstract
Idiopathic pulmonary fibrosis is a complex disease of unknown etiology. Environmental factors can affect disease susceptibility via epigenetic effects. Few studies explore global DNA methylation in lung fibroblasts, but none have focused on transforming growth factor beta-1 (TGF-β1) as a potential modifier of the DNA methylome. Here we analyzed changes in methylation and gene transcription in normal and IPF fibroblasts following TGF-β1...
Paper Details
Title
Transforming growth factor beta 1 induces methylation changes in lung fibroblasts
Published Date
Oct 11, 2019
Journal
Volume
14
Issue
10
Pages
e0223512 - e0223512
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