Antagonism of the interleukin 4 receptor α promotes TH1‐signalling among T cells from patients with atopic dermatitis after stimulation
Abstract
Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease. Molecular characterization of AD shows an underlying inflammation with tissue infiltration of T helper (T H ) 2 cells and increased IL‐4 and IL‐13. The multifaceted roles of IL‐4 and IL‐13 in allergic disease development make IL‐4Rα an attractive target for treatment strategies, and a neutralizing monoclonal antibody which antagonizes the effects of both IL‐4 and IL‐13...
Paper Details
Title
Antagonism of the interleukin 4 receptor α promotes TH1‐signalling among T cells from patients with atopic dermatitis after stimulation
Published Date
Nov 3, 2019
Volume
91
Issue
1
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