DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging
Abstract
SUMMARY null There are numerous hallmarks of aging in mammals, but no unifying cause has been identified. In budding yeast, aging is associated with a loss of epigenetic information that occurs in response to genome instability, particularly DNA double-strand breaks (DSBs). Mammals also undergo predictable epigenetic changes with age, including alterations to DNA methylation patterns that serve as epigenetic “age” clocks, but what drives these...
Paper Details
Title
DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging
Published Date
Jan 1, 2019
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