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Preoperative Risk Score for Predicting Incomplete Cytoreduction: A 12-Institution Study from the US HIPEC Collaborative

Published on Jan 1, 2020in Annals of Surgical Oncology3.681
· DOI :10.1245/s10434-019-07626-y
Mohammad Y. Zaidi4
Estimated H-index: 4
(Emory University),
Rachel M. Lee1
Estimated H-index: 1
(Emory University)
+ 26 AuthorsCharles A. Staley39
Estimated H-index: 39
(Emory University)
Abstract
Background For patients with peritoneal carcinomatosis undergoing cytoreductive surgery with heated intraperitoneal chemotherapy (CRS/HIPEC), incomplete cytoreduction (CCR2/3) confers morbidity without survival benefit. The aim of this study is to identify preoperative factors which predict CCR2/3.
  • References (39)
  • Citations (1)
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References39
Newest
#1D. Solomon (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
#2Natasha DeNicola (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
Last. Umut Sarpel (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 12
view all 11 authors...
Background Colonoscopy to detect colorectal cancer (CRC) is recommended starting at age 50 years; however, CRC rates are increasing in the prescreening population. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has been proven effective in select patients with peritoneal carcinomatosis (PC) from CRC, although it has not been evaluated specifically in patients < 50 years.
1 CitationsSource
#1Jason M. Foster (UNMC: University of Nebraska Medical Center)H-Index: 10
#2Richard Sleightholm (UNMC: University of Nebraska Medical Center)H-Index: 7
Last. Lynette M Smith (UNMC: University of Nebraska Medical Center)H-Index: 48
view all 8 authors...
Importance Currently, rates of referral of patients with peritoneal metastasis in the United States who qualify for cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) are low, in part because of the misperception of high morbidity and mortality rates. However, patients requiring major gastrointestinal surgical procedures with similar complication rates are routinely referred. Objective To evaluate the relative safety of CRS/HIPEC. Design, Setting, and Parti...
7 CitationsSource
#1Michael Kuncewitch (Wake Forest University)H-Index: 2
#2Edward A. Levine (Wake Forest University)H-Index: 54
Last. Konstantinos I. Votanopoulos (Wake Forest University)H-Index: 21
view all 4 authors...
Peritoneal surface disease (PSD) has historically been used interchangeably with the term peritoneal carcinomatosis (PC) and has a dismal natural history. A variety of malignant pathologies, including colorectal and appendiceal primary tumors, can disseminate throughout the peritoneal cavity, leading to bowel obstruction and death. In general, peritoneal spread from high-grade appendiceal and colorectal primaries has the potential of hepatic and distant spread and best classified as PC. Low-grad...
2 CitationsSource
#1Kim GovaertsH-Index: 1
#2K. ChandrakumaranH-Index: 18
Last. Brendan J Moran FrcsiH-Index: 54
view all 8 authors...
Abstract Aim Pseudomyxoma peritonei (PMP) is an uncommon malignancy, generally originating from a ruptured epithelial tumour of the appendix. Despite successful cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), some patients recur. Currently there are no guidelines on the methods, frequency and intensity of follow-up. Methods Between 1994 and 2016, 1070 patients underwent surgery for a perforated epithelial tumour of the appendix, predominantly with PMP. Overall ...
2 CitationsSource
#1Omer AzizH-Index: 32
#2Ihab JaradatH-Index: 1
Last. Sarah T O'DwyerH-Index: 29
view all 9 authors...
BACKGROUND:Appendix adenocarcinomas are rare tumors with propensity for peritoneal metastasis. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy is an established treatment with curative intent, but, to date, studies reporting survival have been heterogeneous with regard to their
8 CitationsSource
The treatments for peritoneal metastases have evolved over 30 years. Now the concepts that guided clinicians are being tested in clinical trials to optimize standardized treatment regimens. The essential features of a successful management plan are cytoreductive surgery combined with cancer chemotherapy in a large volume of intraperitoneal fluid administered into the peritoneal space. The cytotoxicity of the cancer chemotherapy is maximized by moderate hyperthermia. The patients must be carefull...
3 CitationsSource
#1Federica BrunoH-Index: 2
#2Dario BarattiH-Index: 42
Last. Marcello DeracoH-Index: 43
view all 9 authors...
Abstract Background The differential diagnosis between diffuse malignant peritoneal mesothelioma (DMPM) and other peritoneal surface malignancies (PSM) is still challenging. Serum mesothelin and osteopontin are increasingly used as markers of pleural mesothelioma, but their role in DMPM is unclear. We assessed the diagnostic and prognostic values of mesothelin, osteopontin, CEA, CA19.9, CA125, and CA15.3 in DMPM patients. Methods Markers were dosed before cytoreductive surgery and hyperthermic i...
3 CitationsSource
#1Eleonora Ghisoni (UNITO: University of Turin)H-Index: 4
#2Dionyssios KatsarosH-Index: 58
Last. Riccardo PonzoneH-Index: 32
view all 15 authors...
Background Optimal cytoreduction (macroscopic Residual Tumor, RT = 0) is the best survival predictor factor in epithelial ovarian cancer (EOC). It doesn’t exist a consolidated criteria to predict optimal surgical resection at interval debulking surgery (IDS). The aim of this study is to develop a predictive model of complete cytoreduction at IDS.
6 CitationsSource
#1J.-B. Delhorme (UDS: University of Strasbourg)H-Index: 6
#2F. Severac (UDS: University of Strasbourg)H-Index: 2
Last. Cécile Brigand (UDS: University of Strasbourg)H-Index: 20
view all 16 authors...
5 CitationsSource
#1William F. MoranoH-Index: 3
#2Marian KhaliliH-Index: 2
Last. Jesus EsquivelH-Index: 20
view all 5 authors...
5 CitationsSource
Cited By1
Newest
#1JC Chen (The Ohio State University Wexner Medical Center)
#2Eliza W. Beal (The Ohio State University Wexner Medical Center)H-Index: 10
Last. Jordan M. Cloyd (The Ohio State University Wexner Medical Center)H-Index: 9
view all 6 authors...
BACKGROUND: Cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) is indicated for patients with peritoneal dissemination of appendiceal cancer. The role of neoadjuvant chemotherapy (NAC) before CRS-HIPEC remains controversial. METHODS: A retrospective review of adult patients who underwent CRS +/- HIPEC for metastatic appendiceal cancer between 2000-2017 was performed. Patients who received NAC followed by surgery were compared with those who underwent su...
Source
#1M. Haroon A. Choudry (University of Pittsburgh)H-Index: 3
#2David L. Bartlett (University of Pittsburgh)H-Index: 49
Last. Kiran K. Turaga (U of C: University of Chicago)H-Index: 25
view all 4 authors...
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