Mitochondrial heteroplasmy beyond the oocyte bottleneck
Abstract
Inheritance of the mitochondrial genome does not follow the rules of conventional Mendelian genetics. The mitochondrial DNA (mtDNA) is present in many copies per cell and is inherited through the maternal germline. In addition, mutations in the mtDNA will give rise to heteroplasmy, the coexistence of different mtDNA variants within a single cell, whose levels can vary considerably between cells, organs or organisms. The inheritance and...
Paper Details
Title
Mitochondrial heteroplasmy beyond the oocyte bottleneck
Published Date
Jan 1, 2020
Volume
97
Pages
156 - 166
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