LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease

Volume: 134, Pages: 104626 - 104626
Published: Feb 1, 2020
Abstract
LRRK2 has been implicated in endolysosomal function and likely plays a central role in idiopathic Parkinson's disease (iPD). In iPD, dopaminergic neurons within the substantia nigra are characterized by increased LRRK2 kinase activity, endolysosomal deficits, and accumulation of autophagic vesicles with incompletely degraded substrates, including α-synuclein. Although LRRK2 has been implicated in endolysosomal and autophagic function, it remains...
Paper Details
Title
LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease
Published Date
Feb 1, 2020
Volume
134
Pages
104626 - 104626
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