Improving In vitro Evaluation Capabilities of Cardiac Assist Devices through a Validated Exercise Simulation

Cardiac assist devices require thorough in vitro evaluation prior to in vivo animal trials, which is often undertaken in mock circulatory loops. To allow for best possible device development, mock circulatory loops need to be able to simulate a variety of patient scenarios. Transition from rest to exercise is one of the most commonly simulated patient scenarios, however, to validate in vitro exercise test beds, baseline data on how the healthy...