High-throughput sequencing of the transcriptome and chromatin accessibility in the same cell.
Abstract
Single-cell RNA sequencing can reveal the transcriptional state of cells, yet provides little insight into the upstream regulatory landscape associated with open or accessible chromatin regions. Joint profiling of accessible chromatin and RNA within the same cells would permit direct matching of transcriptional regulation to its outputs. Here, we describe droplet-based single-nucleus chromatin accessibility and mRNA expression sequencing...
Paper Details
Title
High-throughput sequencing of the transcriptome and chromatin accessibility in the same cell.
Published Date
Oct 14, 2019
Journal
Volume
37
Issue
12
Pages
1452 - 1457
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Notes
History