SIRT2 deacetylates GRASP55 to facilitate post-mitotic Golgi assembly

Sirtuin 2 (SIRT2) is an NAD-dependent sirtuin deacetylase that regulates microtubule and chromatin dynamics, gene expression, cell cycle progression as well as nuclear envelope reassembly. Recent proteomic analyses have identified Golgi proteins as SIRT2 interactors, indicating that SIRT2 may also play a role in Golgi structure formation. Here we show that SIRT2 depletion causes Golgi fragmentation and impairs Golgi reassembly at the end of...