Newborn Screening for Vitamin B12 Deficiency in Germany—Strategies, Results, and Public Health Implications

Objective To evaluate a systematic newborn screening (NBS) strategy for vitamin B12 deficiency. Study design In a prospective single-center NBS study, a systematic screening strategy for vitamin B12 deficiency was developed and evaluated. Tandem-mass spectrometry screening was complemented by 2 second-tier strategies, measuring methylmalonic/3-OH-propionic/methylcitric acid, and homocysteine from dried blood spots. Results In a cohort of 176 702...