Dynamic Emergence of Observed and Hidden Intra-tumor Heterogeneity
Abstract
Intra-tumor heterogeneity is frequently observed in cancer patients, and it is associated with therapeutic resistance and disease relapse. However, its systematic assessment is still limited and often unfeasible. Here, we use a mathematical model of tumor progression to decipher how multiple clones emerge and organize into complex architectures. We found a trade-off between cancer cell alteration and proliferation rates that defines a transition...
Paper Details
Title
Dynamic Emergence of Observed and Hidden Intra-tumor Heterogeneity
Published Date
Nov 1, 2019
Journal
Volume
21
Pages
157 - 167
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Notes
History