Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity

Gender influences obesity-related complications, including diabetes. Females are more protected from insulin resistance after diet-induced obesity, which may be related to fat accumulation and muscle insulin sensitivity. FoxOs regulate muscle atrophy and are targets of insulin action, but their role in muscle insulin sensitivity and mitochondrial metabolism is unknown. We measured muscle insulin signaling, mitochondrial energetics, and metabolic...